|
T5471 |
GUANABENZ
|
|
Adrenergic Receptor
|
|
GUANABENZ is a Central alpha-2 Adrenergic Agonist. The mechanism of action of guanabenz is as an Adrenergic alpha2-Agonist. |
|
T6792 |
BQ-123
|
BQ123 |
Endothelin Receptor
|
|
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. |
|
T7686 |
Ramiprilat
|
|
RAAS
|
|
Ramiprilat is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. |
|
T21957 |
Guanabenz hydrochloride
|
NE56490 |
Adrenergic Receptor
|
|
Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects. |
|
T22368 |
Metyrosine
|
α-Methyltyrosine |
COX
|
|
Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressu... |
|
T22398 |
Phenidone
|
1-phenyl-3-pyrazolidinone |
Lipoxygenase
,
COX
|
|
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg... |
|
T6581 |
Methyclothiazide
|
Duretic,Enduron,Aquatensen |
Others
,
Carbonic Anhydrase
|
|
Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease. |
|
T4277 |
Osilodrostat
|
LCI699 |
Glucocorticoid Receptor
,
Others
,
Hydroxylase
|
|
Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM). |
|
T0145 |
Felodipine
|
CGH-869 |
Calcium Channel
,
Autophagy
|
|
Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor. |
|
T21454 |
Nicardipine
|
Cardene,Dagan,Antagonil,Flusemide |
Calcium Channel
|
|
Nicardipine (Cardene), a calcium channel blockers belonging to the dihydropyridine class, is a drug used to treat angina and high blood pressure. |
|
T6716 |
Valsartan
|
Diovan,Tareg,CGP 48933 |
RAAS
|
|
Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension. |
|
T4488 |
GSK-25
|
GSK25 |
ROCK
,
S6 Kinase
,
mTOR
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
|
T28482 |
Firibastat
|
QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150 |
Aminopeptidase
|
|
Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively... |
|
T8315 |
1-Cyclohexyl-3-dodecyl urea
|
CDU,N-Cyclohexyl-N-dodecyl urea,NCND |
Epoxide Hydrolase
|
|
1-Cyclohexyl-3-dodecyl urea (NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. |
|
T26745 |
BAY 73-1449
|
BAY-73-1449,BAY73-1449 |
Others
|
|
BAY-73-1449 is an antagonist of prostacyclin receptor. |
|
T2547 |
Droxidopa
|
SM5688,DOPS,L-DOPS |
Adrenergic Receptor
|
|
Droxidopa (L-DOPS) is an orally available prodrug of norepinephrine that is used in the treatment of symptomatic orthostatic hypotension due to neurogenic causes of autonomic failure. |
|
T3518 |
GSK269962A
|
GSK269962B,GSK 269962,GSK269962A HCl |
ROCK
,
S6 Kinase
|
|
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
|
T0197 |
Terazosin hydrochloride
|
Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic |
Adrenergic Receptor
|
|
Terazosin hydrochloride (Hytrin) , a selective alpha1-antagonist, can treat the benign prostatic hyperplasia (BPH). It also can lower blood pressure, so it is a drug of choice for patients with prostate enlargement and h... |
|
T1215 |
Nicardipine hydrochloride
|
RS-69216,Nicardipine HCl,YC-93 Hydrochloride |
Calcium Channel
,
Adrenergic Receptor
,
AChR
,
Autophagy
|
|
Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks cal... |
|
T22419 |
S-Methylisothiourea sulfate
|
(S)-Methylisothiourea sulfate |
NOS
,
NO Synthase
,
HSV
|
|
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1]. |
|
T6991 |
Nitroprusside disodium dihydrate
|
Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate |
Guanylate cyclase
,
Autophagy
|
|
Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood. |
|
T20656 |
Verapamil
|
NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil |
P450
,
Calcium Channel
,
P-gp
|
|
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias... |
|
T1050 |
Prazosin hydrochloride
|
Prazosin hydrochloride,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,Minipress |
Potassium Channel
,
MRP
,
Adrenergic Receptor
,
ABC
,
Autophagy
|
|
Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic ... |
|
T21395 |
Finerenone
|
BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 |
Glucocorticoid Receptor
|
|
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862... |
|
T6701 |
Terazosin hydrochloride dihydrate
|
Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate |
Adrenergic Receptor
|
|
Terazosin hydrochloride dihydrate (Heitrin dihydrate) is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH). |
|
T1010 |
Verapamil hydrochloride
|
Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride |
P450
,
Calcium Channel
,
P-gp
|
|
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent. |
|
T78216 |
Cis-ent-Tadalafil
|
(6S,12aR)-Tadalafil,Tadalafil, (6S,12aR)-,cis-ent-IC-351 |
Others
|
|
cis-ent-Tadalafil (cis-ent-IC-351) is a potent and selective PDE5 inhibitor that lowers blood pressure. cis-ent-Tadalafil is a potent and selective PDE5 inhibitor that reduces blood pressure. |
|
TP2058L |
Catestatin acetate
|
Catestatin acetate(142211-96-9 free base) |
Endogenous Metabolite
,
AChR
|
|
Catestatin acetate is a non-competitive antagonist of nAChR and inhibits catecholamine release. Catestatin acetate regulates cardiac function and blood pressure. |
|
T6863 |
Isosorbide Mononitrate
|
Isosorbide-5-mononitrate,Imdur,Mononit,Corangin,Monoket,Elantan |
Others
,
Autophagy
|
|
Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure. |
|
T12478L |
Pinacidil
|
S 1230,P 1134,S-1230,P-1134,P1134 |
Potassium Channel
|
|
Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention. |
|
T1666L |
Fludrocortisone
|
9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,Fludrocortisone acetate,Astonin,9α-Fluorcortisol |
Others
|
|
Fludrocortisone (Florinef) is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. Fludrocortisone can be used to studies on treating low blood pressure. |
|
TP1295 |
Angiotensin I (human, mouse, rat)
|
Angiotensin 1 Human |
Others
|
|
Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).Angiotensin is a peptide hormone that causes vasoconstriction and an in... |
|
T22466 |
Adenosine receptor A1 antagonist 5
|
|
cAMP
|
|
Adenosine receptor A1 antagonist 5 acts as an adenosine antagonist, is an oxypurine, acts as an insecticide and pest control agent, and has an inhibitory effect on elevated blood pressure. |
|
T34146 |
Propanidid
|
FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol |
GABA Receptor
|
|
Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure. |
|
T31640 |
Enrasentan
|
SB-217242,SB 217242,SB217242 |
Endothelin Receptor
|
|
Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial function. |
|
T6835 |
Fenoldopam mesylate
|
Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526 |
Dopamine Receptor
|
|
Fenoldopam mesylate (Corlopam mesylate) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation. |
|
TP2446L |
Angiotensin amide acetate
|
Angiotensin amide acetate(53-73-6 Free base) |
Others
|
|
Angiotensin amide acetate is a derivative of Angiotensin amide, an octapeptide amide that increases blood pressure through vasoconstriction. |
|
T7143 |
Alagebrium chloride
|
ALT711 |
Others
,
Endogenous Metabolite
|
|
Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic |
|
T4661 |
PKG drug G1
|
|
PKA
|
|
PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism. |
|
T1299 |
3-Pyridinemethanol
|
Nicotinyl alcohol,Roniacol |
Others
|
|
3-Pyridinemethanol (Roniacol) is an alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE. |
|
T6262 |
Evacetrapib
|
LY2484595 |
CETP
|
|
Evacetrapib (LY2484595) (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3. |
|
T1057 |
Azilsartan
|
TAK-536 |
RAAS
|
|
Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres... |
|
T0999 |
Clevidipine
|
Clevidipine butyrate,Cleviprex |
Calcium Channel
,
AChR
|
|
Clevidipine (Clevidipine butyrate) is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option. |
|
T21546 |
NG,NG-dimethyl-L-Arginine dihydrochloride
|
|
NO Synthase
|
|
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1]. |
|
T1462 |
Captopril
|
SQ 14225,SQ-14534,SA333 |
RAAS
|
|
Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure. |
|
T1439 |
Lacidipine
|
SN-305,GX-1048,GR-43659X |
Apoptosis
,
Calcium Channel
,
Reactive Oxygen Species
|
|
Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specifi... |
|
T5511 |
L-765314
|
|
Adrenergic Receptor
|
|
L-765314 is a drug which acts as a potent and selective antagonist for the Alpha-1 adrenergic receptor subtype α1B. It has mainly been used to investigate the role of α1B receptors in the regulation of blood pressure. |
|
T4512 |
Magnesium glycinate
|
magnesium 2-aminoacetate,Magnesium diglycinate |
Others
|
|
Magnesium glycinate (magnesium 2-aminoacetate) is a supplement that boost magnesium levels in people with a deficiency of the mineral. Magnesium is a vital nutrient for regulating many body processes, including muscle an... |
|
T0207 |
Ranolazine dihydrochloride
|
RS 43285,Ranolazine 2HCl |
Calcium Channel
,
Sodium Channel
,
Autophagy
|
|
Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or h... |
|
T20570 |
Labetalol
|
Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne |
Adrenergic Receptor
|
|
Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat... |
